卷积融合文本和异质信息网络的学术论文推荐算法

针对交互数据稀疏和推荐多样性问题,基于卷积协同过滤推荐框架提出卷积融合文本和异质信息网络的学术论文推荐算法（WN-APR）。首先学习不同语义下用户和论文的多样化特征,缓解数据稀疏问题;然后基于外积设计不同语义特征相互增强的方式融合它们,并使用三维卷积神经网络代替二维卷积神经网络充分挖掘不同特征对性能的影响;最后改进贝叶斯个性化排序损失函数增强推荐多样性。在CiteuLike-a、CiteuLike-t数据集上的实验结果表明,相比于基线模型,WN-APR在准确率和多样性的四个指标上都有所提升。     

冰期河湖与大气的热交换模型

河湖与大气的热交换模型是计算分析冰凌形成、发展、消融时空变化规律的基础。基于现有太阳辐射、长波辐射、蒸发和对流模型研究成果,以现场冰情要素观测及历史天气资料为依据,建立了适用于冰期计算分析的河湖与大气的热交换非线性模型。提出了考虑晴天散射的太阳辐射计算模型,以Iziomon公式计算大气长波逆辐射,以俄罗斯冬季公式计算蒸发和对流。基于现场观测雪面或冰面温度Ts接近于Ta的实际,提出了在Ts=Ta点对河湖与大气的多参数非线性热交换模型线性化,然后利用历史天气资料,采用线性回归的方法确定热交换系数hsa。研究证实:(1)气象站风级或者风速资料一般不能准确估计地势低洼河面的风速;(2)采用典型年历史天气资料得到的hsa可用于预测其他年的热交换;(3)hsa与Ta成正比,且北京、沈阳、保定、包头的hsa的平均值10.0 W/(m2·℃);(4)漠河和拉萨的hsa略小于北京等地区。     

鄱阳湖水龄时空特征和影响因素分析

换水能力是表征湖泊水动力和污染物输移扩散的关键指标,鄱阳湖水文情势波动显著,换水能力时空特征和影响因素复杂。本文选取水龄描述鄱阳湖换水能力,建立鄱阳湖水龄模型,研究了鄱阳湖水龄的时空特征和影响因素,分析了水龄对鄱阳湖江湖关系演变的响应规律。结果表明:(1)鄱阳湖水龄具有显著的时空异质性。夏季和秋季水龄明显大于冬季和春季,碟形湖和湖湾区域水龄明显大于主河道和滩地。(2)湖口水位和流域入流是影响鄱阳湖水龄的主要因素。湖口水位对鄱阳湖水龄的影响大于流域入流;湖口水位越高则鄱阳湖水龄越大,流域入流与之相反;鄱阳湖水龄年内显著波动的主要原因是湖口水位的年内显著变化。(3)2003年后,随着江湖关系的演变,鄱阳湖水龄有所减小,其中秋季减小最为明显。研究成果能为鄱阳湖水资源保护提供科学支撑,也可为其他大型湖泊换水能力研究提供参考。     

基于水化学和环境同位素的准格尔煤田地下水循环特征

为揭示准格尔煤田地区地下水循环特征,运用水化学技术、水汽轨迹模型和环境同位素等方法分析不同水体水化学特征、环境同位素特征、大气降水主要来源、地表水及地下水转化关系。结果表明:地表水矿化度低,呈弱碱-偏碱性,水化学类型以HCO_3·SO_4·Cl-Ca型水为主;地下水整体矿化度低,偏弱碱性,主要以HCO_3-Na·Ca型、Cl-Na型、HCO_3-Ca·Mg型、HCO_3·Cl-Na型水为主;黄河水δ(D)平均值为-79.6‰、δ(~(18)O)平均值为-10.47‰,第四系地下水δ(D)平均值为-66.25‰、δ(~(18)O)平均值为-9.1‰,白垩系地下水δ(D)值为-70.6‰、δ(~(18)O)值为-9.3‰,石炭-二叠系地下水δ(D)平均值为-77.07‰、δ(~(18)O)平均值为-9.9‰,寒武-奥陶系地下水δ(D)平均值为-75.73‰、δ(~(18)O)平均值为-10.06‰;大气降水受极地气团和季风影响,主要来源为西风带水汽、地表水和地下水水汽蒸发再循环;断层带、褶皱轴部裂隙带为不同含水层间主要导水通道,大气降水和黄河为地下水主要补给来源;高承压水头寒武-奥陶系岩溶裂隙水越流补给第四系松散孔隙水和砂岩裂隙水,第四系松散孔隙水通过地层间不整合接触面裂隙发育带向下补给石炭-二叠系砂岩裂隙水,黄河水对寒武-奥陶系地下水的补给比例受地质构造发育的影响较大。     

基于种群多样性的自适应PSO算法求解VRPSPD问题

为有效求解逆向物流车辆路径(VRPSPD)模型,本文提出一种基于种群多样性的自适应PSO算法(SDAPSO)。在SDAPSO运行时,根据种群多样性,自适应地对种群中运行较差的粒子进行扰动操作,提升这些粒子向最优解收敛的能力;同时,对全局最优粒子进行概率扰动,以增加种群的多样性。标准检测函数的仿真结果表明SDAPSO算法是对基本PSO算法的有效改进。在对VRPSPD模型求解中,通过与其它粒子群算法相比,表明SDAPSO是求解该类问题的一种有效方法。     

基于非参数乘法回归模型的农业景观步甲空间分布模拟

农业生产引起的景观变化是导致生物多样性丧失的重要原因,为评估农业景观结构变化对物种多样性的影响,探索农业景观物种空间模拟的方法,研究应用非参数乘法回归(NPMR)模型结合田间步甲取样数据,分析了步甲群落多样性、主要物种存在/不存在与取样点周围边长为200 m景观内景观结构之间的关系,建立研究区物种-景观分布预测模型,结合地理信息系统(GIS)技术建立研究区群落/物种空间分布预测图。结果表明:在群落水平上,景观结构对步甲群落多样性的影响不显著; 在物种水平上,黄斑青步甲(Chlaenius micans)、淡鞘婪步甲(Harpalus pallidipennis)受斑块密度的影响显著(p<0.05),黄斑青步甲、后斑青步甲(Chlaenius posticalis)和单齿婪步甲(Harpalus simplicide)受半自然生境类型数的影响显著(p<0.05),单齿蝼步甲(Scarites terricola)受半自然生境比例的影响显著(p<0.05),而蠋步甲(Dolichus halensis)受景观结构的影响较为复杂。通过模型预测,输出研究区域6个主要物种的空间分布模拟图,进一步分析发现在研究区域内,对景观结构较为敏感的6个步甲物种主要分布在农田与半自然生境相接的狭长地带。因此,利用非参数乘法回归模型可以很好地模拟步甲物种对农田景观结构的响应及其在景观中的空间分布变化。200 m×200 m尺度下,尽管步甲群落多样性不受景观结构的显著影响,但是存在部分步甲物种对景观结构响应显著,但不同物种对景观结构的响应不同。增加农田地块间半自然生境,并合理改善景观配置异质性将有利于对景观结构变化敏感步甲物种的维持。     

多样性制导分段进化的基因表达式编程

为了解决基于传统基因表达式编程（GEP）的函数挖掘及其改进算法仍然存在局部优化的缺陷这一问题,提出了以基因组多样性制导的分阶段进化挖掘算法DGGEP。给出了GEP 进化阶段和基因组多样性评估模式的定义;提出了描述进化阶段的进化因子概念和分阶段进化策略;采用动态遗传算子设计和群体规模控制方法,使进化更快速跳出局部最优。实验表明了新算法的有效性,能减少进化停滞代数65％以上,使群体的平均适应度提高12%以上。     

Telomere Length in Metaphase Chromosomes of Human Triploid Zygotes

The human lifespan is strongly influenced by telomere length (TL) which is defined in a zygote—when two highly specialised haploid cells form a new diploid organism. Although TL is a variable parameter, it fluctuates in a limited range. We aimed to establish the determining factors of TL in chromosomes of maternal and paternal origin in human triploid zygotes. Using Q-FISH, we examined TL in the metaphase chromosomes of 28 human triploid zygotes obtained from 22 couples. The chromosomes’ parental origin was identified immunocytochemically through weak DNA methylation and strong hydroxymethylation in the sperm-derived (paternal) chromosomes versus strong DNA methylation and weak hydroxymethylation in the oocyte-derived (maternal) ones. In 24 zygotes, one maternal and two paternal chromosome sets were identified, while the four remaining zygotes contained one paternal and two maternal sets. For each zygote, we compared mean relative TLs between parental chromosomes, identifying a significant difference in favour of the paternal chromosomes, which attests to a certain “imprinting” of these regions. Mean relative TLs in paternal or maternal chromosomes did not correlate with the respective parent’s age. Similarly, no correlation was observed between the mean relative TL and sperm quality parameters: concentration, progressive motility and normal morphology. Based on the comparison of TLs in chromosomes inherited from a single individual’s gametes with those in chromosomes inherited from different individuals’ gametes, we compared intraindividual (intercellular) and interindividual variability, obtaining significance in favour of the latter and thus validating the role of heredity in determining TL in zygotes. A comparison of the interchromatid TL differences across the chromosomes from sets of different parental origin with those from PHA-stimulated lymphocytes showed an absence of a significant difference between the maternal and paternal sets but a significant excess over the lymphocytes. Therefore, interchromatid TL differences are more pronounced in zygotes than in lymphocytes. To summarise, TL in human zygotes is determined both by heredity and parental origin; the input of other factors is possible within the individual’s reaction norm.     

Real-Time Monitoring the Effect of Cytopathic Hypoxia on Retinal Pigment Epithelial Barrier Functionality Using Electric Cell-Substrate Impedance Sensing (ECIS) Biosensor Technology

Disruption of retinal pigment epithelial (RPE barrier integrity is a hallmark feature of various retinal blinding diseases, including diabetic macular edema and age-related macular degeneration, but the underlying causes and pathophysiology are not completely well-defined. One of the most conserved phenomena in biology is the progressive decline in mitochondrial function with aging leading to cytopathic hypoxia, where cells are unable to use oxygen for energy production. Therefore, this study aimed to thoroughly investigate the role of cytopathic hypoxia in compromising the barrier functionality of RPE cells. We used Electric Cell-Substrate Impedance Sensing (ECIS) system to monitor precisely in real time the barrier integrity of RPE cell line (ARPE-19) after treatment with various concentrations of cytopathic hypoxia-inducing agent, Cobalt(II) chloride (CoCl₂). We further investigated how the resistance across ARPE-19 cells changes across three separate parameters: R_b (the electrical resistance between ARPE-19 cells), α (the resistance between the ARPE-19 and its substrate), and C_m (the capacitance of the ARPE-19 cell membrane). The viability of the ARPE-19 cells and mitochondrial bioenergetics were quantified with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and seahorse technology, respectively. ECIS measurement showed that CoCl₂ reduced the total impedance of ARPE-19 cells in a dose dependent manner across all tested frequencies. Specifically, the ECIS program’s modelling demonstrated that CoCl₂ affected R_b as it begins to drastically decrease earlier than α or C_m, although ARPE-19 cells’ viability was not compromised. Using seahorse technology, all three concentrations of CoCl₂ significantly impaired basal, maximal, and ATP-linked respirations of ARPE-19 cells but did not affect proton leak and non-mitochondrial bioenergetic. Concordantly, the expression of a major paracellular tight junction protein (ZO-1) was reduced significantly with CoCl_2-treatment in a dose-dependent manner. Our data demonstrate that the ARPE-19 cells have distinct dielectric properties in response to cytopathic hypoxia in which disruption of barrier integrity between ARPE-19 cells precedes any changes in cells’ viability, cell-substrate contacts, and cell membrane permeability. Such differences can be used in screening of selective agents that improve the assembly of RPE tight junction without compromising other RPE barrier parameters.     

触变成形镁合金的热处理研究

介绍了触变成形镁合金的热处理研究现状以及合金元素在热处理过程中的作用,热处理过程中的析出相形态、数量以及在基体中的分布与合金的力学性能有着密切的联系.